Cyrebro vs Palo Alto Networks: MDR comparison 2026
Cyrebro and Palo Alto Networks are both Platform vendors. Cyrebro works with your existing tools and targets SMB and Mid-market organizations, while Palo Alto Networks requires its own security platform and serves Mid-market and Enterprise. Cyrebro includes 4 attack surfaces in base pricing (Endpoint, Cloud, SaaS, Network), compared to 5 for Palo Alto Networks (Endpoint, Cloud, SaaS, Identity, Network).
Key differences at a glance
Full comparison
Which should you choose?
Choose Cyrebro if:
- •SMBs and mid-market teams that want MDR layered on top of their existing EDR and cloud tools
- •Organizations that need fast onboarding (hours) and do not want to manage a SIEM themselves
- •MSPs looking for a white-label, multi-tenant SOC platform
Choose Palo Alto Networks if:
- •Enterprise organizations already invested in the Palo Alto ecosystem (NGFW, Prisma, WildFire) wanting native MDR
- •US government and defense organizations needing FedRAMP Moderate, DoD IL5, StateRAMP compliance
- •Large enterprises facing sophisticated threats needing Unit 42 threat intelligence (500B events/day)
- •You need Identity coverage included in base pricing
- •Breach warranty matters to you (Palo Alto Networks offers one, Cyrebro does not)
Bottom line: Palo Alto Networks is the choice if you want a single-vendor stack with deep integration. Cyrebro is better if you have existing tools and want flexibility.
Frequently asked questions
What is the main difference between Cyrebro and Palo Alto Networks?
Cyrebro is a Platform vendor that is technology-agnostic (works with your existing tools). Palo Alto Networks is a Platform vendor that is platform-native (requires their own security stack). Cyrebro covers 4 attack surfaces in base pricing vs. 5 for Palo Alto Networks.
How do Cyrebro and Palo Alto Networks differ in response capabilities?
Cyrebro supports 6 autonomous actions (endpoint isolation, process termination, network containment, account disable, file quarantine, custom playbooks) and approval is configurable. Palo Alto Networks supports 6 autonomous actions (endpoint isolation, process termination, network containment, account disable, file quarantine, custom playbooks) and approval is configurable. Incident response is included with Cyrebro and not included with Palo Alto Networks.
How does Cyrebro pricing compare to Palo Alto Networks?
Cyrebro pricing: Custom-quoted pricing. Palo Alto Networks pricing: Cortex XDR Pro: ~$81/endpoint/year reported (platform only, pricing sources vary). Unit 42 MDR service is additional custom pricing. Total cost depends on endpoints, tier, coverage scope, and contract terms.. Watch for with Cyrebro: No public pricing means you cannot benchmark against competitors without a sales call; Data ingestion volume into the Security Data Lake may drive cost increases as your environment grows. Watch for with Palo Alto Networks: Cortex XDR/XSIAM platform license is a significant prerequisite cost on top of MDR service fee; Cortex Data Lake storage costs are separate and scale with data volume.
Should I choose Cyrebro or Palo Alto Networks?
Choose Cyrebro if: sMBs and mid-market teams that want MDR layered on top of their existing EDR and cloud tools. Choose Palo Alto Networks if: enterprise organizations already invested in the Palo Alto ecosystem (NGFW, Prisma, WildFire) wanting native MDR. Cyrebro is not ideal for buyers who need US-based SOC operations or follow-the-sun coverage across multiple regions. Palo Alto Networks is not ideal for sMBs or budget-constrained organizations (significant platform prerequisites plus MDR service fee).